Home Itens selecionados Provedores de dados OAI Créditos Sobre Ajuda

			Busca avançada
	Provedor de dados Genet. Mol. Biol. (1) Autor Baptista,Francielle (1) Becker,Tânia C.A. (1) Castro-Prado,Marialba A.A. de (1) Chiuchetta,Simone J.R. (1) Palavra-chave Antineoplastic drug (1) Aspergillus nidulans (1) Ethidium bromide (1) Intercalating agent (1) Mitotic crossing over (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2003 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Increase in mitotic recombination in diploid cells of Aspergillus nidulans in response to ethidium bromide Genet. Mol. Biol. Becker,Tânia C.A.; Chiuchetta,Simone J.R.; Baptista,Francielle; Castro-Prado,Marialba A.A. de. Ethidium bromide (EB) is an intercalating inhibitor of topoisomerase II and its activities are related to chemotherapeutic drugs used in anti-cancer treatments. EB promotes several genotoxic effects in exposed cells by stabilising the DNA-enzyme complex. The recombinagenic potential of EB was evaluated in our in vivo study by the loss of heterozygosity of nutritional markers in diploid Aspergillus nidulans cells through Homozygotization Index (HI). A DNA repair mutation, uvsZ and a chromosome duplication DP (II-I) were introduced in the genome of tested cells to obtain a sensitive system for the recombinagenesis detection. EB-treated diploid cells had HI values significantly greater than the control at both concentrations (4.0 x 10-3 and 5.0 x 10-3 mM).... Tipo: Info:eu-repo/semantics/article Palavras-chave: Antineoplastic drug; Aspergillus nidulans; Ethidium bromide; Intercalating agent; Mitotic crossing over. Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572003000300026 Registros recuperados: 1 Primeira ... 1 ... Última

Empresa Brasileira de Pesquisa Agropecuária - Embrapa Todos os direitos reservados, conforme Lei n° 9.610 Política de Privacidade Área restrita		Embrapa Parque Estação Biológica - PqEB s/n° Brasília, DF - Brasil - CEP 70770-901 Fone: (61) 3448-4433 - Fax: (61) 3448-4890 / 3448-4891 SAC: https://www.embrapa.br/fale-conosco